Processivity and Velocity for Motors Stepping on Periodic Tracks.

ABSTRACT: Processive molecular motors enable cargo transportation by assembling into dimers capable of taking several consecutive steps along a cytoskeletal filament. In the well-accepted hand-over-hand stepping mechanism, the trailing motor detaches from the track and binds the filament again in the leading position. This requires fuel consumption in the form of ATP hydrolysis and coordination of the catalytic cycles between the leading and the trailing heads. Alternate stepping pathways also exist, including inchworm-like movements, backward steps, and foot stomps. Whether all the pathways are coupled to ATP hydrolysis remains to be determined. Here, to establish the principles governing the dynamics of processive movement, we present a theoretical framework that includes all of the alternative st

SUBMITTER: Mugnai ML 

PROVIDER: S-EPMC7136348 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature