Transcriptomic Analysis of Monocyte-Derived Non-Phagocytic Macrophages Favors a Role in Limiting Tissue Repair and Fibrosis.

ABSTRACT: Monocyte-derived macrophages are readily differentiating cells that adapt their gene expression profile to environmental cues and functional needs. During the resolution of inflammation, monocytes initially differentiate to reparative phagocytic macrophages and later to pro-resolving non-phagocytic macrophages that produce high levels of IFNβ to boost resolutive events. Here, we performed in-depth analysis of phagocytic and non-phagocytic myeloid cells to reveal their distinct features. Unexpectedly, our analysis revealed that the non-phagocytic compartment of resolution phase myeloid cells is composed of Ly6C^medF4/80^- and Ly6C^hiF4/80^lo monocytic cells in addition to the previously described Ly6C^-F4/80⁺ satiated macrophages.

SUBMITTER: Butenko S 

PROVIDER: S-EPMC7136412 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature