Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes.

ABSTRACT: Extracellular vesicles with their molecular cargo can modulate target cell response and may affect the pathogenesis of diseases. The extracellular vesicles containing micro-RNAs (miRNAs), which are often studied as disease biomarkers, but rarely as mediators of the disease development. The role of extracellular vesicles derived miRNAs in type 1 diabetes is currently not well established. We observed a fraction of blood plasma extracellular vesicles positive for membrane proteins potentially associated with insulin-producing beta-cells and identified differentially expressed extracellular vesicles derived miRNAs in individuals with type 1 diabetes. These differentially expressed extracellular vesicles derived human miRNAs in participants with type 1 diabetes and participants with Langerhans

SUBMITTER: Tesovnik T 

PROVIDER: S-EPMC7136501 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature