Pharmacological Studies on the Role of 5-HT_{1 A} Receptors in Male Sexual Behavior of Wildtype and Serotonin Transporter Knockout Rats.

ABSTRACT: Brain serotonin (5-HT) neurotransmission plays an important role in male sexual behavior and it is well established that activating 5-HT_{1 A} receptors in rats facilitate ejaculatory behavior. However, the relative contribution of 5-HT_{1 A} somatodendritic autoreceptors and heteroreceptors in this pro-sexual behavior is unclear. Moreover, it is unclear whether the contribution of somatodendritic 5-HT_{1 A} autoreceptors and postsynaptic 5-HT_{1 A} heteroreceptors alter when extracellular 5-HT levels are chronically increased. Serotonin transporter knockout (SERT^-/-) rats exhibit enhanced extracellular 5-HT levels and desensitized 5-HT_{1 A} receptors. These rats model neurochemical c

SUBMITTER: Esquivel-Franco DC 

PROVIDER: S-EPMC7136541 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature