Short-Term Efficacy and Tolerability of Paroxetine Versus Placebo for Panic Disorder: A Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Objective

To explore the short-term efficacy and tolerability of paroxetine in the treatment of panic disorder in adults.

Methods

Multiple electronic databases were searched to find randomized controlled trials (RCTs) on paroxetine and panic disorder. The primary efficacy outcomes were: the mean change compared to the baseline in the total number of full panic attacks, Clinical Global Impression-Severity of Illness (CGI-S) score, and the proportion of participants with zero full panic attacks and with a 50% or greater reduction in the number of full panic attacks. The tolerability outcomes included withdrawal rate and the incidence of adverse events (AEs).

Results

13RCTs were included. The pooled analyses showed patients who received paroxetine experienced greater imp

SUBMITTER: Zhang B 

PROVIDER: S-EPMC7136560 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature