Methylation-Driven Genes Identified as Novel Prognostic Indicators for Thyroid Carcinoma.

ABSTRACT:

Background

Aberrant DNA methylation plays an crucial role in tumorigenesis through regulating gene expression. Nevertheless, the exact role of methylation in the carcinogenesis of thyroid cancer and its association with prognosis remains unclear. The purpose of this study is to explore the DNA methylation-driven genes in thyroid cancer by integrative bioinformatics analysis.

Methods

The transcriptome profiling data and DNA methylation data of thyroid cancer were downloaded from The Cancer Genome Atlas (TCGA) database. The methylmix R package was used to screen DNA methylation-driven genes in thyroid cancer. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were conducted to annotate the function of methylation-driven genes. Univariate Cox regress

SUBMITTER: Lv L 

PROVIDER: S-EPMC7136565 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature