Dosimetric Evaluation of PSMA PET-Delineated Dominant Intraprostatic Lesion Simultaneous Infield Boosts.

ABSTRACT:

Purpose

Prostate cancer is multifocal. However, there often exists a single dominant focus in the gland responsible for driving the biology of the disease. Dose escalation to the dominant lesion is a proposed strategy to increase tumor control. We applied radiobiological modeling to evaluate the dosimetric feasibility and benefit of dominant intraprostatic lesion simultaneous in-field boosts (DIL-SIB) to the gross tumor volume (GTV), defined using a novel molecular positron emission tomography (PET) probe (18F-DCFPyL) directed against prostate specific membrane antigen (PSMA).

Methods and materials

Patients with clinically localized, biopsy-proven prostate cancer underwent preoperative [¹⁸F]-DCFPyL PET/computed tomography (CT). DIL-SIB plans were generated by impo

SUBMITTER: Goodman CD 

PROVIDER: S-EPMC7136625 | biostudies-literature | 2020 Mar-Apr

REPOSITORIES: biostudies-literature