Bacterial Template Synthesis of Multifunctional Nanospindles for Glutathione Detection and Enhanced Cancer-Specific Chemo-Chemodynamic Therapy.

ABSTRACT: Biological synthetic methods of nanoparticles have shown great advantages, such as environmental friendliness, low cost, mild reaction conditions, and enhanced biocompatibility and stability of products. Bacteria, as one of the most important living organisms, have been utilized as bioreducing nanofactories to biosynthesize many metal nanoparticles or compounds. Here, inspired by the disinfection process of KMnO₄, we for the first time introduce bacteria as both the template and the reducing agent to construct a novel tumor microenvironment-responsive MnO _x -based nanoplatform for biomedical applications in various aspects. It is found that the bacterium/MnO _x -based nanospindles (EM NSs) can efficiently encapsulate the chemotherapeutic agent

SUBMITTER: Bao YW 

PROVIDER: S-EPMC7136754 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature