Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Stroke among Patients with Hypertension.

ABSTRACT:

Background

Dysregulations of AQP7 and AQP9 were found to be related to lipid metabolism abnormality, which had been proven to be one of the mechanisms of stroke. However, limited epidemiological studies explore the associations between AQP7 and AQP9 and the risk of stroke among patients with hypertension in China.

Aims

We aimed to investigate the associations between genetic variants in AQP7 and AQP9 and the risk of stroke among patients with hypertension, as well as to explore gene-gene and gene-environment interactions.

Methods

Baseline blood samples were drawn from 211 cases with stroke and 633 matched controls. Genomic DNA was extracted by a commercially available kit. Genotyping of 5 single nucleotide polymorphisms (SNPs)

SUBMITTER: Tu Q 

PROVIDER: S-EPMC7136773 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature