Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals.

ABSTRACT:

Importance

The Anti-Amyloid Treatment in Asymptomatic Alzheimer disease (A4) Study is an ongoing prevention trial in clinically normal older individuals with evidence of elevated brain amyloid. The large number of participants screened with amyloid positron emission tomography (PET) and standardized assessments provides an unprecedented opportunity to evaluate factors associated with elevated brain amyloid.

Objective

To investigate the association of elevated amyloid with demographic and lifestyle factors, apolipoprotein E (APOE), neuropsychological testing, and self- and study partner reports of cognitive function.

Design, setting, and participants

This cross-sectional study included screening data in the Anti-Amyloid Treatment in Asymptomatic Alzheimer Disease (A4)

SUBMITTER: Sperling RA 

PROVIDER: S-EPMC7136861 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature