Association of urinary concentrations of phthalate metabolites with quinolinic acid among women: A potential link to neurological disorders.

ABSTRACT:

Background

Quinolinic acid (QA), a neuroactive metabolite produced during tryptophan degradation, is implicated in the pathogenesis of several neurological disorders. Phthalates are structurally similar to QA, and exposure to phthalates has demonstrated increased QA production and excretion in rodent studies. We recently showed that very high exposure to dibutyl phthalate was associated with higher concentrations of urinary QA in men. However, no human studies examined the associations between background (low) phthalate exposures and QA.

Objectives

To examine the associations of urinary concentrations of phthalate metabolites with QA.

Methods

Female participants (N = 126) who participated in a prospective cohort study at the Massachusetts General Hospital Fertility Ce

SUBMITTER: Nassan FL 

PROVIDER: S-EPMC7136979 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature