Adrenomedullin inhibits tumor metastasis and is associated with good prognosis in triple-negative breast cancer patients.

ABSTRACT: BACKGROUND:Cancer metastasis is the major reason for cancer-related deaths, but the mechanism of cancer metastasis still unclear. Adrenomedullin (ADM), a peptide hormone, functions as a local paracrine and autocrine mediator with multiple biological activities, such as angiogenesis, cell proliferation, and anti-inflammation. However, the expression and potential function of ADM in triple-negative breast cancer (TNBC) remain unclear. METHODS:Real-time polymerase chain reaction and western blotting were performed to examine the expression of ADM in TNBC tissues and cell lines. A total of 458 TNBC tissue samples and adjacent nontumor tissue samples were detected by immunochemistry to determine the correlation between ADM expression and clinicopathological characteristics. We determined the ro

SUBMITTER: Liu LL 

PROVIDER: S-EPMC7137045 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature