CD19+CD24hiCD38hi regulatory B cells: a potential immune predictive marker of severity and therapeutic responsiveness of hepatitis C.

ABSTRACT: OBJECTIVES:Hepatitis C virus (HCV) infection is associated with abnormal immune responses. Since regulatory T (Tregs) and B (Bregs) cells modulate the progression of infectious diseases, this study aimed at examining how these cells are involved with the development of HCV infection. METHODS:The frequencies of circulating Bregs and Tregs were characterized using flow cytometry. Both the association and dynamic changes of these cells with related clinical parameters were analyzed after Direct-Acting Antiviral (DAA) agent treatments. Additionally, both regulatory B and T and naïve B and T cells were sorted and stimulated with healthy or HCV sera in vitro. RESULTS:Bregs frequency in HCV-infected patients increased significantly and were positively correlated with levels of sera HCV RNA load,

SUBMITTER: Fang Q 

PROVIDER: S-EPMC7137049 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature