Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.

ABSTRACT: Consumption of a high-fat diet has been associated with an increased risk of developing colorectal cancer (CRC). However, the effects of the interaction between dietary fat content and the aryl hydrocarbon receptor (AhR) on colorectal carcinogenesis remain unclear. Mainly known for its role in xenobiotic metabolism, AhR has been identified as an important regulator for maintaining intestinal epithelial homeostasis. Although previous research using whole body AhR knockout mice has revealed an increased incidence of colon and cecal tumors, the unique role of AhR activity in intestinal epithelial cells (IECs) and modifying effects of fat content in the diet at different stages of sporadic CRC development are yet to be elucidated. In the present study, we have examined the effects of a high-fa

SUBMITTER: Garcia-Villatoro EL 

PROVIDER: S-EPMC7137094 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature