Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility.

ABSTRACT:

Background

Herein, we collected currently published data to comprehensively evaluate the impact of the FCGR2A (Fc fragment of IgG receptor IIa) rs1801274 and MUC5B (mucin 5B, oligomeric mucus/gel-forming) rs35705950 variations on susceptibility to pneumonia diseases.

Methods

We retrieved case-control studies from three online databases and applied the statistical approach of meta-analysis for a series of pooling analyses.

Results

A total of fourteen case-control studies were included for FCGR2A rs1801274; while thirty-one case-control studies were included for MUC5B rs35705950. No significant difference between pneumonia cases and controls for FCGR2A rs1801274 was found. However, MUC5B rs35705950 was significantly associated with pneumonia susceptibility in the whole

SUBMITTER: Shi X 

PROVIDER: S-EPMC7137230 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature