Landscape of copy number aberrations in esophageal squamous cell carcinoma from a high endemic region of South Africa.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with one of the highest world incidences in the Eastern Cape region of South Africa. Several genome wide studies have been performed on ESCC cohorts from Asian countries, North America, Malawi and other parts of the world but none have been conducted on ESCC tumors from South Africa to date, where the molecular pathology and etiology of this disease remains unclear. We report here tumor associated copy number changes observed in 51 ESCC patients' samples from the Eastern Cape province of South Africa.

Methods

We extracted tumor DNA from 51 archived ESCC specimens and interrogated tumor associated DNA copy number changes using Affymetrix® 500 K SNP array technology. The Genomic Identification of Sign

SUBMITTER: Brown J 

PROVIDER: S-EPMC7137242 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature