Cytokine response in human leptospirosis with different clinical outcomes: a systematic review.

ABSTRACT: BACKGROUND:Leptospirosis is a neglected zoonotic disease which is a major challenge for clinicians and public health professionals in tropical countries. The cytokine storm during the second (immune) phase is thought to be a major contributory factor for the leptospirosis disease severity. We aim to summarize evidence for cytokine response in leptospirosis at different clinical outcomes. METHODS:A systematic review was carried out to examine the cytokine response in leptospirosis patients using relevant scientific databases. Reference lists of the selected articles were also screened. Quality of the selected studies was assessed by using the National Institutes of Health Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. RESULTS:Of the 239 articles retrieved in t

SUBMITTER: Senavirathna I 

PROVIDER: S-EPMC7137275 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature