Associated factors of poor treatment outcomes in patients with giant cell arteritis: clinical implication of large vessel lesions.

ABSTRACT:

Background

Relapses frequently occur in giant cell arteritis (GCA), and long-term glucocorticoid therapy is required. The identification of associated factors with poor treatment outcomes is important to decide the treatment algorithm of GCA.

Methods

We enrolled 139 newly diagnosed GCA patients treated with glucocorticoids between 2007 and 2014 in a retrospective, multi-center registry. Patients were diagnosed with temporal artery biopsy, 1990 American College of Rheumatology classification criteria, or large vessel lesions (LVLs) detected by imaging based on the modified classification criteria. Poor treatment outcomes (non-achievement of clinical remission by week 24 or relapse during 52 weeks) were evaluated. Clinical remission was defined as the absence of clinical signs

SUBMITTER: Sugihara T 

PROVIDER: S-EPMC7137303 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature