A Pharmacoepidemiologic Study of the Safety and Effectiveness of Clindamycin in Infants.

ABSTRACT:

Background

Despite the absence of adequate safety or efficacy data, clindamycin is widely prescribed in the neonatal intensive care unit. We evaluated the association between clindamycin exposure and adverse events, as well as antibiotic effectiveness in infants.

Methods

This was a retrospective cohort study of infants receiving clindamycin before postnatal day 121 who were discharged from a Pediatrix Medical Group neonatal intensive care unit (1997-2015). Using a previously developed pharmacokinetic model, we performed simulations to predict clindamycin exposure based on available dosing data. We used multivariable logistic regression to evaluate the association between clindamycin exposure and safety outcomes during and after clindamycin therapy. We reported the proportion

SUBMITTER: Greenberg RG 

PROVIDER: S-EPMC7137351 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature