CD45^dimCD34⁺CD38^-CD133⁺ cells have the potential as leukemic stem cells in acute myeloid leukemia.

ABSTRACT:

Background

Leukemia stem cells (LSCs) in play an important role in the initiation, relapse, and progression of acute myeloid leukemia (AML), and in the development of chemotherapeutic drug resistance in AML. Studies regarding the detection of LSCs and the development of novel therapies for targeting them are extensive. The identification of LSCs and targeting therapies for them has been continuously under investigation.

Methods

We examined the levels of CD45^dimCD34⁺CD38^-CD133⁺ cells in bone marrow samples from patients with hematological malignancies and healthy controls, using four-color flow cytometry.

Results

Interestingly, the CD45^dimCD34⁺CD38^-CD133⁺ cells were highly expressed

SUBMITTER: Heo SK 

PROVIDER: S-EPMC7137473 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature