Dataset Information

Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy.

ABSTRACT:

Background

We aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.

Main body

We included in our observational study all patients with episodic or chronic migraine treated with erenumab during the year 2019 in the Abruzzo region, central Italy, and with a 6-month follow-up. We included 89 patients; 76 (85.4%) received 6 doses of erenumab, 11 (12.4%) autonomously withdrew the drug due to perceived inefficacy, and 2 (2.2%) due to adverse events. Seventy-eight patients (87.6%) were female, with a mean age of 46.8 ± 11.2 years; 84 (94.4%) had chronic migraine, and 64 (71.9%) medication overuse. All patients had ≥2 prior preventive treatment failures. Fifty-three patients (69.7%) had a 50% decrease in monthly migraine days (MMDs) within the first three doses; 46 (71.9%) of 64 patients withdrew medication overuse. In the 76 patients who completed a 6-dose treatment, erenumab decreased median MMDs from 19 (interquartile range [IQR] 12-27.5) to 4 (IQR 2-9.5; P < 0.001), median monthly days of analgesic use from 10 (IQR 4.5-20) to 2 IQR 0-5; P < 0.001), and median monthly days of triptan use from 5 (IQR 0-15.5) to 1 (IQR 0-4; P < 0.001). We recorded 27 adverse events in 20 (22.5%) patients, the most common being constipation (13.5%). One adverse event, i.e. allergic reaction, led to treatment discontinuation in one patient.

Conclusions

Our real-life data confirm the efficacy and tolerability of erenumab for the prevention of migraine in a difficult-to-treat population of patients with a high prevalence of chronic migraine and medication overuse.

SUBMITTER: Ornello R

PROVIDER: S-EPMC7137484 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy.

Ornello Raffaele R Casalena Alfonsina A Frattale Ilaria I Gabriele Amleto A Affaitati Giannapia G Giamberardino Maria Adele MA Assetta Maurizio M Maddestra Maurizio M Marzoli Fabio F Viola Stefano S Cerone Davide D Marini Carmine C Pistoia Francesca F Sacco Simona S

The journal of headache and pain 20200407 1

<h4>Background</h4>We aimed to assess the efficacy and safety of erenumab, a fully human monoclonal antibody inhibiting the calcitonin gene-related peptide receptor (CGRPr), for the prevention of migraine in a real-life setting.<h4>Main body</h4>We included in our observational study all patients with episodic or chronic migraine treated with erenumab during the year 2019 in the Abruzzo region, central Italy, and with a 6-month follow-up. We included 89 patients; 76 (85.4%) received 6 doses of e ...[more]

PMID: 32264820

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Dataset Information

Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy.

Background

Main body

Conclusions

Publications

Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy.

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