Leucine-rich α2-glycoprotein-1 upregulation in plasma and kidney of patients with lupus nephritis.

ABSTRACT:

Background

Increased leucine-rich α2-glycoprotein-1 (LRG1) has been observed in various inflammatory and autoimmune diseases. We aimed to explore the expression and role of LRG1 in lupus nephritis (LN).

Methods

Plasma LRG1 (pLRG1) was measured by enzyme-linked immunosorbent assay in 101 patients with renal biopsy-proven LN and 21 healthy controls (HC). Relationships between pLRG1 and clinical and pathological characteristics were analyzed. The expression of LRG1 in peripheral blood leukocytes and kidney was detected by flow cytometry, immunohistochemistry and immunofluorescence, respectively. Further cell experiments were focused on the role of LRG1.

Results

We found that LRG1 was expressed in plasma, some peripheral blood leukocytes, proximal tubule and several infla

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7137487 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature