Identification of Key Genes and Pathways for Enchondromas by Bioinformatics Analysis.

ABSTRACT:

Background

The risk of malignant transformation of enchondromas (EC) toward central chondrosarcoma is increased up to 35%, while the exact etiology of EC is unknown. The purpose of this research was to authenticate gene signatures during EC and reveal their potential mechanisms in occurrence and development of EC.

Methods

The gene expression profiles was acquired from Gene Expression Omnibus database (no. GSE22855). The gene ontology (GO), protein-protein interaction (PPI) network and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were utilized to identify differentially expressed genes (DEGs).

Results

Finally, 242 DEGs were appraisal, containing 200 overregulated genes and 42 downregulated genes. The outcomes of GO analysis indicated that

SUBMITTER: Wu T 

PROVIDER: S-EPMC7137642 | biostudies-literature | 2020 Jan-Mar

REPOSITORIES: biostudies-literature