Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies.

ABSTRACT:

Importance

Leukocyte telomere length (LTL) is a trait associated with risk of cardiovascular disease and cancer, the 2 major disease categories that largely define longevity in the United States. However, it remains unclear whether LTL is associated with the human life span.

Objective

To examine whether LTL is associated with the life span of contemporary humans.

Design, setting, and participants

This cohort study included 3259 adults of European ancestry from the Cardiovascular Health Study (CHS), Framingham Heart Study (FHS), and Women's Health Initiative (WHI). Leukocyte telomere length was measured in 1992 and 1997 in the CHS, from 1995 to 1998 in the FHS, and from 1993 to 1998 in the WHI. Data analysis was conducted from February 2017 to December 2019.

Main ou

SUBMITTER: Arbeev KG 

PROVIDER: S-EPMC7137690 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature