Reduced Cardiac Index Reserve and Hypovolemia in Severe Falciparum Malaria.

ABSTRACT:

Background

Impaired microvascular perfusion is central to the development of coma and lactic acidosis in severe falciparum malaria. Refractory hypotension is rare on admission but develops frequently in fatal cases. We assessed cardiac function and volume status in severe falciparum malaria and its prognostic significance.

Methods

Patients with severe (N = 101) or acute uncomplicated falciparum malaria (N = 83) were recruited from 2 hospitals in India and Bangladesh, and healthy participants (N = 44) underwent echocardiography.

Results

Patients with severe malaria had 38% shorter left ventricular (LV) filling times and 25% shorter LV ejection times than healthy participants because of tachycardia; however, stroke volume, LV internal diameter in diastole (LVIDd), and L

SUBMITTER: Kingston HWF 

PROVIDER: S-EPMC7137886 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature