The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma.

ABSTRACT: It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation o

SUBMITTER: Herrera-Merchan A 

PROVIDER: S-EPMC7138163 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature