An Activatable NIR Fluorescent Rosol for Selectively Imaging Nitroreductase Activity.

ABSTRACT: Hypoxia (pO₂ ≤ ~1.5%) is an important characteristic of tumor microenvironments that directly correlates with resistance against first-line therapies and tumor proliferation/infiltration. The ability to accurately identify hypoxic tumor cells/tissue could afford tailored therapeutic regimens for personalized treatment, development of more-effective therapies, and discerning the mechanisms underlying disease progression. Fluorogenic constructs identifying aforesaid cells/tissue operate by targeting the bioreductive activity of primarily nitroreductases (NTRs), but collectively present photophysical and/or physicochemical shortcomings that could limit effectiveness. To overcome these limitations, we present the rational design, development, and evaluation of the first activ

SUBMITTER: Klockow JL 

PROVIDER: S-EPMC7138224 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature