Rapid calcification propensity testing in blood using a temperature controlled microfluidic polymer chip.

ABSTRACT: Phosphate toxicity is a major threat to cardiovascular health in chronic kidney disease. It is associated with oxidative stress, inflammation and the accumulation of calcium phosphate commonly known as calcification in soft tissues leading to functional disorders of blood vessels. An improved calcification propensity test for the assessment of phosphate toxicity was developed, which measures the velocity of calcium phosphate mineralization from colloidal precursors in vitro. This so called T50 test measures the transformation from a primary into a secondary form of nanosized colloidal plasma protein-calcium phosphate particles known as calciprotein particles. The T50 test in its previous form required a temperature controlled nephelometer and several hours of continuous measurement, which

SUBMITTER: Bavendiek J 

PROVIDER: S-EPMC7138308 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature