Sex Differences in Kidney Function and Metabolism Assessed Using Hyperpolarized [1-¹³C]Pyruvate Interleaved Spectroscopy and Nonspecific Imaging.

ABSTRACT: Metabolic sex differences have recently been shown to be particularly important in tailoring treatment strategies. Sex has a major effect on fat turnover rates and plasma lipid delivery in the body. Differences in kidney structure and transporters between male and female animals have been found. Here we investigated sex-specific renal pyruvate metabolic flux and whole-kidney functional status in age-matched healthy Wistar rats. Blood oxygenation level-dependent and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) were used to assess functional status. Hyperpolarized [1-¹³C]pyruvate was used to assess the metabolic differences between male and female rats. Female rats had a 41% ± 3% and 41% ± 5% lower absolute body and kidney weight, respectively, than age-matched

SUBMITTER: Wen Y 

PROVIDER: S-EPMC7138520 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature