Microstructure Modeling of High b-Value Diffusion-Weighted Images in Glioblastoma.

ABSTRACT: Apparent diffusion coefficient has limits to differentiate solid tumor from normal tissue or edema in glioblastoma (GBM). This study investigated a microstructure model (MSM) in GBM using a clinically available diffusion imaging technique. The MSM was modified to integrate with bi-polar diffusion gradient waveforms, and applied to 30 patients with newly diagnosed GBM. Diffusion-weighted (DW) images acquired on a 3 T scanner with b-values from 0 to 2500 s/mm² were fitted in volumes of interest (VOIs) of solid tumor to obtain the apparent restriction size of intracellular water (ARS), the fractional volume of intracellular water (V_in ), and extracellular (D_ex ) water diffusivity. The parameters in solid tumor were compared with those of o

SUBMITTER: Li Y 

PROVIDER: S-EPMC7138521 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature