Prognostic values of immune scores and immune microenvironment-related genes for hepatocellular carcinoma.

ABSTRACT: It is crucial to grasp the characteristics of tumour immune microenvironment to improve effects of immunotherapy. In this study, the immune and stromal scores of 371 cases were calculated for quantitative analysis of immune and stromal cell infiltration in the tumour microenvironment of hepatocellular carcinoma (HCC). The weighted gene co-expression network analysis and protein-protein interaction network were analysed to identify immune microenvironment-related genes. The results showed that patients with high immune scores had a higher 4-year recurrence-free rate. TP53, CTNNB1, and AXIN1 mutations significantly varied with immune scores. In immune score-related modules analysis, Kyoto encyclopaedia of genes and genomes pathways and gene ontology terms were closely related to immune proce

SUBMITTER: Ge PL 

PROVIDER: S-EPMC7138561 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature