EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke.

ABSTRACT:

Background

Ischemic stroke is a devastating disease, often resulting in death or permanent neurological deficits. EMMPRIN/CD147 is a plasma membrane protein that induces the production of matrix metalloproteinases (MMPs), which contribute to secondary damage after stroke by disrupting the blood brain barrier (BBB) and facilitating peripheral leukocyte infiltration into the brain.

Results

CD147 surface expression increased significantly after stroke on infiltrating leukocytes, astrocytes and endothelial cells, but not on resident microglia. Inhibition of CD147 reduced MMP levels, decreased ischemic damage, and improved functional, cognitive and histological outcomes after experimental ischemic stroke in both young and aged mice. In stroke patients, high levels of serum CD147

SUBMITTER: Patrizz A 

PROVIDER: S-EPMC7138568 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature