Impaired brain network architecture in Cushing's disease based on graph theoretical analysis.

ABSTRACT: To investigate the whole functional brain networks of active Cushing disease (CD) patients about topological parameters (small world and rich club et al.) and compared with healthy control (NC). Nineteen active CD patients and twenty-two healthy control subjects, matched in age, gender, and education, underwent resting-state fMRI. Graph theoretical analysis was used to calculate the functional brain network organizations for all participants, and those for active CD patients were compared for and NCs. Active CD patients revealed higher global efficiency, shortest path length and reduced cluster efficiency compared with healthy control. Additionally, small world organization was present in active CD patients but higher than healthy control. Moreover, rich club connections, feeder connection

SUBMITTER: Xu CX 

PROVIDER: S-EPMC7138581 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature