Associations between human milk oligosaccharides and growth in infancy and early childhood.

ABSTRACT:

Background

Breastfeeding modulates infant growth and protects against the development of obesity. However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.

Objective

Our objective was to determine the association between maternal HMO composition and child growth during the first 5 y of life. In addition, the association between maternal prepregnancy BMI and HMO composition was assessed.

Methods

Human milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland. HMO composition in these milk samples was analyzed by HPLC. Child growth dat

SUBMITTER: Lagstrom H 

PROVIDER: S-EPMC7138667 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature