A Health-Conscious Food Pattern Is Associated with Prediabetes and Gut Microbiota in the Malmo Offspring Study.

ABSTRACT:

Background

Diet is a determinant of gut microbiota. Both diet and gut microbiota have been linked to metabolic diseases.

Objective

We aimed to examine data-driven food patterns in relation to the prevalence of prediabetes and gut microbiota composition and food pattern-associated bacteria in relation to prediabetes.

Methods

Food patterns were extracted using principal component analysis in 1726 individuals (aged 18-71 y, 55% women, mean BMI = 25.5 kg/m2) without diabetes from the population-based Malmö Offspring Study. The gut (fecal) microbiota was analyzed by sequencing the 16S ribosomal RNA gene (V1-V3 region). Prediabetes classification was based on fasting glucose ≥6.0 mmol/L and/or glycated hemoglobin ≥42 mmol/L at baseline and/or type 2 diabetes diagnosis durin

SUBMITTER: Ericson U 

PROVIDER: S-EPMC7138670 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature