Effect of vitamin D3 supplementation on vascular and metabolic health of vitamin D-deficient overweight and obese children: a randomized clinical trial.

ABSTRACT:

Background

Obese children are vulnerable to vitamin D deficiency and impaired cardiovascular health; vitamin D replenishment might improve their cardiovascular health.

Objectives

The aims were to determine, in vitamin D-deficient overweight and obese children, whether supplementation with vitamin D3 1000 or 2000 IU/d is more effective than 600 IU/d in improving arterial endothelial function, arterial stiffness, central and systemic blood pressure (BP), insulin sensitivity (1/fasting insulin concentration), fasting glucose concentration, and lipid profile and to explore whether downregulation of adipocytokines and markers of systemic inflammation underlies vitamin D effects.

Methods

We conducted a randomized, double-masked, controlled clinical trial in 225 10- to 18-y-

SUBMITTER: Rajakumar K 

PROVIDER: S-EPMC7138671 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature