Reactivation Viremia in Pediatric Sepsis.

ABSTRACT:

Objectives

Reactivation viremia is associated with adverse clinical outcomes and immune dysfunction in adults with sepsis. We determined the incidence of viremia and its association with clinical outcomes and immune paralysis phenotype in children with severe sepsis.

Design

Prospective cohort study.

Setting

Single academic PICU from September 2016 to March 2018.

Patients

Fifty-nine patients 2-17 years old treated for severe sepsis.

Interventions

None.

Measurements and main results

We performed real-time polymerase chain reaction assays on whole blood specimens to determine the incidence of cytomegalovirus. Cytomegalovirus was detected in three patients (5%). All patients with cytomegalovirus viremia were seropositive, with an incidence of 13% in t

SUBMITTER: Han M 

PROVIDER: S-EPMC7138713 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature