Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease.

ABSTRACT:

Introduction

We investigated plasma proteomic markers of astrocytopathy, brain degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset Alzheimer's disease (EOAD and LOAD).

Methods

Plasma was analyzed using ultra-sensitive immuno-based assays from 33 EOAD, 30 LOAD, and 36 functionally normal older adults.

Results

Principle component analyses identified 3 factors: trophic (BDNF, VEGF, TGFβ), degenerative (GFAP, NfL), and inflammatory (TNFα, IL-6, IP-10, IL-10). Trophic factor was elevated in both AD groups and associated with cognition and gray matter volumes. Degenerative factor was elevated in EOAD, with higher levels associated with worse functioning in this group. Biomarkers of inflammation were not significantly different between groups

SUBMITTER: Elahi FM 

PROVIDER: S-EPMC7138729 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature