Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions.

ABSTRACT: A series of strained Ru(II) complexes were studied for potential anticancer activity in hypoxic tissues. The complexes were constructed with methylated ligands that were photolabile and an imidizo[4,5-f][1,10]phenanthroline ligand that contained an appended aromatic group to potentially allow for contributions of ligand-centered excited states. A systematic variation of the size and energy of the aromatic group was performed using systems containing 1-4 fused rings, and the photochemical and photobiological behaviors of all complexes were assessed. The structure and nature of the aromatic group had a subtle impact on photochemistry, altering environmental sensitivity, and had a significant impact on cellular cytotoxicity and photobiology. Up to 5-fold differences in cytotoxicity were obser

SUBMITTER: Roque J 

PROVIDER: S-EPMC7138741 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature