Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance.

ABSTRACT:

Objective

This study compared the effects of alternate-day fasting (ADF) with those of daily calorie restriction (CR) on body weight and glucoregulatory factors in adults with overweight or obesity and insulin resistance.

Methods

This secondary analysis examined the data of insulin-resistant individuals (n = 43) who participated in a 12-month study that compared ADF (25% energy needs on "fast days"; 125% energy needs on alternating "feast days") with CR (75% energy needs every day) and a control group regimen.

Results

In insulin-resistant participants, weight loss was not different between ADF (-8% ± 2%) and CR (-6% ± 1%) by month 12, relative to controls (P < 0.0001). Fat mass and BMI decreased (P < 0.05) similarly from ADF and CR. ADF produced greater decreases (P <

SUBMITTER: Gabel K 

PROVIDER: S-EPMC7138754 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature