A multivariable Mendelian randomization to appraise the pleiotropy between intelligence, education, and bipolar disorder in relation to schizophrenia.

ABSTRACT: Education and intelligence are highly correlated and inversely associated with schizophrenia. Counterintuitively, education genetically associates with an increased risk for the disease. To investigate why, this study applies a multivariable Mendelian randomization of intelligence and education. For those without college degrees, older age of finishing school associates with a decreased likelihood of schizophrenia-independent of intelligence-and, hence, may be entangled with the health inequalities reflecting differences in education. A different picture is observed for schooling years inclusive of college: more years of schooling increases the likelihood of schizophrenia, whereas higher intelligence distinctly and independently decreases it. This implies the pleiotropy between years of sc

SUBMITTER: Adams CD 

PROVIDER: S-EPMC7138794 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature