Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis.

ABSTRACT: Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against intrinsic random variations. However, our understanding of these noise-buffering mechanisms remains incomplete. Here, we showed that appropriate glycemic control confers developmental homeostasis in the fruit fly Drosophila. We found that circulating glucose levels are buffered by trehalose metabolism, which acts as a glucose sink in circulation. Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size. Whereas wild-

SUBMITTER: Matsushita R 

PROVIDER: S-EPMC7138798 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature