Short Acquisition Time Super-Resolution Ultrasound Microvessel Imaging via Microbubble Separation.

ABSTRACT: Super-resolution ultrasound localization microscopy (ULM), based on localization and tracking of individual microbubbles (MBs), offers unprecedented microvascular imaging resolution at clinically relevant penetration depths. However, ULM is currently limited by the requirement of dilute MB concentrations to ensure spatially sparse MB events for accurate localization and tracking. The corresponding long imaging acquisition times (tens of seconds or several minutes) to accumulate sufficient isolated MB events for full reconstruction of microvasculature preclude the clinical translation of the technique. To break this fundamental tradeoff between acquisition time and MB concentration, in this paper we propose to separate spatially overlapping MB events into sub-populations, each with sparser

SUBMITTER: Huang C 

PROVIDER: S-EPMC7138805 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature