Linoleic acid induces metabolic stress in the intestinal microorganism Bifidobacterium breve DSM 20213.

ABSTRACT: Despite clinical and research interest in the health implications of the conjugation of linoleic acid (LA) by bifidobacteria, the detailed metabolic pathway and physiological reasons underlying the process remain unclear. This research aimed to investigate, at the molecular level, how LA affects the metabolism of Bifidobacterium breve DSM 20213 as a model for the well-known LA conjugation phenotype of this species. The mechanisms involved and the meaning of the metabolic changes caused by LA to B. breve DSM 20213 are unclear due to the lack of comprehensive information regarding the responses of B. breve DSM 20213 under different environmental conditions. Therefore, for the first time, an untargeted metabolomics-based approach was used to depict the main changes in the metabolic profiles o

SUBMITTER: Senizza A 

PROVIDER: S-EPMC7138814 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature