Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis.

ABSTRACT: Cold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure. However, systemic activation of the β3-AR pathway inevitably increases blood pressure, a significant risk factor for cardiovascular disease, and, thus, limits its application for the treatment of obesity. To activate fat thermogenesis under tight spatiotemporal control without external stimuli, here, we report an implantable wireless optogenetic device that bypasses the β-AR pathway and triggers Ca²⁺ cycling selectively in adipocytes. The wireless optogenetics stimulation in the subcutaneous adipose tissue potently activates Ca²⁺ cycling fat thermogenesis and increases whole-body energy expenditure witho

SUBMITTER: Tajima K 

PROVIDER: S-EPMC7138828 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature