Ontology highlight
ABSTRACT:
SUBMITTER: Mindrebo JT
PROVIDER: S-EPMC7138838 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Mindrebo Jeffrey T JT Patel Ashay A Kim Woojoo E WE Davis Tony D TD Chen Aochiu A Bartholow Thomas G TG La Clair James J JJ McCammon J Andrew JA Noel Joseph P JP Burkart Michael D MD
Nature communications 20200407 1
Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative Claisen-like condensation reaction. KSs must recognize multiple chemically distinct ACPs and choreograph a ping-pong mechanism, often in an iterative fashion. Here, we report crystal structures of substrate mimetic bearing ACPs in complex with the ...[more]