Calcification of coronary arteries and aortic valve and circulating a-klotho levels in patients with chronic kidney disease.

ABSTRACT:

Background

Evidence suggests that the anti-aging protein a-Klotho is a central modulator of mineral homeostasis. Circulating a-Klotho exerts endocrine activity and has been implicated in the process of vascular calcification, which is accelerated in patients with chronic kidney disease (CKD) and portends an unfavorable overall prognosis. However, the role of a-Klotho in this process remains unclear. The purpose of this study was to investigate the possible interaction between a-Klotho and the calcification of the aortic valve and coronary arteries in patients with CKD.

Methods

In this study we enrolled a total of 60 adult patients with CKD. Group 1 included 30 participants with CKD stage V and group 2 included 30 participants with CKD stage III.

Results

Participants i

SUBMITTER: Savvoulidis P 

PROVIDER: S-EPMC7139066 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature