Dataset Information

Clinical outcomes and toxicity predictors of thoracic re-irradiation for locoregionally recurrent lung cancer.

ABSTRACT:

Background and purpose

Thoracic re-irradiation may be an alternative treatment for lung cancer patients who develop intrathoracic locoregional recurrence without systemic progression. This study aimed to retrospectively assess locoregional control, clinical outcomes, and toxicities in lung cancer patients who received thoracic re-irradiation.

Materials and methods

We retrospectively reviewed 50 lung cancer patients who received thoracic re-irradiation using conventional photon radiotherapy (RT) and stereotactic body radiotherapy (SBRT) between 2009 and 2017. The correlations of clinicopathologic factors, treatment factors, and dosimetric factors of RT with time to local progression (TTLP), progression-free survival (PFS), and overall survival (OS) after starting thoracic re-irradiation were calculated using log-rank tests and Cox regression models.

Results

The median re-irradiation dose in equivalent dose in 2-Gy fractions was 51.1 Gy, and the mean re-irradiation planning target volume was 201.58 ml. The median mean lung dose (MLD) was 4.18 Gy, and the total lung volumes receiving a dose of 5 Gy (lung V5) and of 20 Gy (V20) were 19.8% and 5.85%, respectively. The TTLP, PFS, and OS were 18.0, 5.9, and 25.1 months, respectively. Lung V5 (p < 0.001), V20 (p = 0.011), and MLD (p = 0.002) were significantly associated with grade ≥2 lung toxicity. Seven (14%) patients developed lethal lung events. Subsequent chemotherapy following thoracic re-irradiation was significantly correlated with lethal lung events (p = 0.009).

Conclusion

Promising local control can be achieved with thoracic re-irradiation in lung cancer patients with locoregional recurrence. However, unexpected lethal lung events may occur, especially in patients receiving systemic therapy following thoracic re-irradiation.

SUBMITTER: Yang WC

PROVIDER: S-EPMC7139144 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Publications

Clinical outcomes and toxicity predictors of thoracic re-irradiation for locoregionally recurrent lung cancer.

Yang Wen-Chi WC Hsu Feng-Ming FM Chen Yu-Hsuan YH Shih Jin-Yuan JY Yu Chong-Jen CJ Lin Zhong-Zhe ZZ Lu Szu-Huai SH Yang James Chih-Hsin JC Cheng Ann-Lii AL Kuo Sung-Hsin SH

Clinical and translational radiation oncology 20200323

<h4>Background and purpose</h4>Thoracic re-irradiation may be an alternative treatment for lung cancer patients who develop intrathoracic locoregional recurrence without systemic progression. This study aimed to retrospectively assess locoregional control, clinical outcomes, and toxicities in lung cancer patients who received thoracic re-irradiation.<h4>Materials and methods</h4>We retrospectively reviewed 50 lung cancer patients who received thoracic re-irradiation using conventional photon rad ...[more]

PMID: 32280792

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Dataset Information

Clinical outcomes and toxicity predictors of thoracic re-irradiation for locoregionally recurrent lung cancer.

Background and purpose

Materials and methods

Results

Conclusion

Publications

Clinical outcomes and toxicity predictors of thoracic re-irradiation for locoregionally recurrent lung cancer.

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