Bio responsive self-assembly of Au-miRNAs for targeted cancer theranostics.

ABSTRACT:

Background

MicroRNA (miRNA) therapeutics are a promising approach to cancer treatment. However, this method faces considerable challenges to achieve tissue-specific, efficient, and safe delivery of miRNAs in vivo.

Methods

Herein, we developed a miRNA delivery system based on the in situ self-assembly of Au-miRNA nanocomplexes (Au-miRNA NCs). Within the cancer microenvironment, we constructed in situ self-assembled Au-miRNA NCs by coincubating gold salt and tumor suppressor mimics, such as let-7a, miRNA-34a, and miRNA-200a.

Findings

The in vitro experiments demonstrated that characteristic in situ self-assembled Au-miRNA NCs were present in cancer cells and can be taken up to inhibit the proliferation of cancer cells effectively. Most importantly, as proven in subcutan

SUBMITTER: Cai W 

PROVIDER: S-EPMC7139156 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature