Evaluation of a Novel Prototype for Pressurized Intraperitoneal Aerosol Chemotherapy.

ABSTRACT: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been suggested as an alternative option for treating peritoneal carcinomatosis (PC). Even with its clinical advantages, the current PIPAC system still suffers from limitations regarding drug distribution area and penetration depth. Thus, we evaluated the new PIPAC system using a novel prototype, and compared its performance to the results from previous studies related with the current MIP® indirectly because the system is currently not available for purchase in the market. The developed prototype includes a syringe pump, a nozzle, and controllers. Drug distribution was conducted using a methylene blue solution for performance test. For penetration depth evaluation, an ex-vivo experiment was performed with porcine tissues in a 3.5

SUBMITTER: Lee HS 

PROVIDER: S-EPMC7139407 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature